A unifying concept in pathology create, communicate, collaborate log-in    register    myfolder       news           education            jobs          meetings           forums          links         community      home > education > e-atlas > histopathology > liver & bile ducts > hepatocellular carcinoma hepatocellular carcinoma    1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 back slide /28 image id: back to index next [hepatocellular carcinoma]. Hepatocellular carcinoma (hcc) is much less common than metastatic tumors to the liver and in most cases pose little difficulty in its histologic identification. Well-differentiated hcc, however, may be difficult to distinguish from normal hepatic parenchyma or hepatocellular adenomas. Three main architectural growth patterns are identified: trabecular (most common), solid, and tubular (acinar, duct-like, pseudo-glandular). This example of well-differentiated hcc shows a trabecular pattern with intervening sinusoids. [hepatocellular carcinoma]. The key to the identification of hcc is its resemblance to hepatocytes, the presence of more than 2-3 cell-thick hepatocellular plates/cords, nuclear atypia, and absence of portal tracts. Hepatocytes in normal adults are arranged in single-cell-thick plates/cords but in hcc the plates/cords are almost always more than 2 cell-thick (microtrabecular pattern) but can be more than 8-10 cell-thick (macrotrabecular pattern). This example of well-differentiated hcc shows a microtrabecular growth pattern with 3-4 cell-thick hepatocellular plates/cords. Note the hepatic plates are separated from each other by sinusoids. [hepatocellular carcinoma]. Well differentiated hcc may sometimes be difficult to distinguish from hepatocellular adenomas. Hepatocellular carcinomas, as opposed to adenomas, show >2 cell-thick plates/cords and nuclear atypia. Adenomas generally show only 1-2 cell-thick plates, no significant atypia and only very rare mitoses. This example of well-differentiated hcc shows polygonal tumor cells with obvious resemblance to hepatocytes but that show enlarged nuclei (high n/c ratio) with prominent nucleoli (two long arrows). viagra for sale buy viagra online australia fast delivery viagra without a doctor prescription viagra without a doctor prescription cheap viagra online generic viagra buy viagra online cheapest viagra price http://classicmotocrossimages.com/mbs-viagra-cheap-buy-canada-gi/ viagra online Note distinct cell membranes and the presence of a dilated bile canaliculus (arrowhead) surrounded by hepatocytes. [hepatocellular carcinoma]. A moderately differentiated hcc is the most easily recognizable form of hcc. This example shows a trabecular growth pattern with dilated sinusoids. [hepatocellular carcinoma]. This example of a moderately differentiated hcc shows nuclear atypia in the form of enlarged convoluted nuclei (arrowhead) but retain the cytopl.

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A Civil War Story
by
Ann DeWitt and Kevin M. Weeks

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Mom%27s Chocie Award

In Entangled In Freedom, main character Isaac is convinced that he must venture outside of Oxford, Georgia if he is to become a liberated slave.  Simultaneously, Abraham Green, slaveholder of Isaac, is concerned about the safety and security of the Green family and farmland during the War Between the States. How far will Abraham Green and Isaac travel with the Confederate States Army 42nd Regiment Georgia Volunteers?  Will Isaac be faced with friend or foe when he steps foot at Camp McDonald, the Georgia Military Institute training camp across from the well-known Lacy Hotel in Big Shanty, Georgia?  Will the family feuds in Tennessee between the Unionists and Confederates impact Isaac's lifelong dreams as he comes to terms that his entire world is entangled in freedom?

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